Your first drink of the night for a better tomorrow

Genetically engineered by a team of PhD microbiologists, ZBiotics® Pre-Alcohol is a probiotic drink that breaks down the byproduct of alcohol responsible for rough mornings after drinking.

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ZBiotics: The World's First Drinking Probiotic

Night out? Wake up thankful. ZBiotics is the patented, science-backed probiotic engineered to break down acetaldehyde, the nasty byproduct that ruins your morning. Simply mix one travel-friendly packet with your first drink. It's the only pre-alcohol probiotic that helps you feel better the next day, so you can enjoy the night and own the morning.

World's first genetically engineered probiotic

Trusted by customers
GRAS & FDA safety compliant
Responsibly engineered
Transparently labeled

How it works

Drink a Pre-Alcohol

For best results, make Pre-Alcohol your first drink of the night.

Drink responsibly

Whether it’s a glass of wine with dinner or going out with friends, pace yourself, hydrate, and get a good night’s sleep.

Enjoy tomorrow

Seize your next day—hit the gym, get outside, play with the kids—make the most of it.

It's not magic,It's science

Alcohol produces acetaldehyde

When we drink, our bodies break down alcohol into an unwanted byproduct called acetaldehyde.

That byproduct is largely responsible for how we feel the day after drinking.

Acetaldehyde builds up in the gut

Acetaldehyde forms in two places: the liver and the gut.

The liver produces an enzyme that removes it quickly. But the gut does not. So acetaldehyde builds up and lingers, filtering out into the rest of our body over time.

Pre-Alcohol breaks it down

Pre-Alcohol helps our gut catch up by temporarily adding a probiotic that can break down acetaldehyde.

This probiotic – Bacillus subtilis ZB183™ – has been engineered to produce the same type of enzyme as our liver: one that digests acetaldehyde.

Proudly built with genetic engineering

The ZBiotics team invented the probiotic in Pre-Alcohol – Bacillus subtilis ZB183™ – using genetic engineering.

Our approach to biotechnology is safety-first and grounded in the strictest ethical principles. We build responsibly or we don’t build at all. Pre-Alcohol undergoes rigorous quality testing at every stage, and we transparently publish our findings on our Quality page

Our Mission

Help people live healthier, richer lives with the world’s first genetically engineered probiotics. By building products that people love, we aim to elevate the GMO conversation and showcase the potential of biology to improve our daily lives.

Unique products, built with genetic engineering

We believe in the power of science to make daily life better. Products like Pre-Alcohol do that in ways nothing else can. And they are only possible because of genetic engineering.

Transparency in our DNA

We share every part of our process, from the engineering underlying our products to who we are as individuals. That’s why each ZBiotics product is labeled “Proudly GMO.”

Setting the standard for GMO Safety

Our highest priority is safety first, always. We’ve pioneered new safety and quality standards in the areas of microbial engineering, probiotic manufacturing, and bottling. And we’ve advocated for these elevated standards outside ZBiotics as well, to people across government, industry, and academia.

Elevating the conversation

Nowadays, the simplistic narrative of “GMO bad, non-GMO good” is so dominant that we see products that don’t even have DNA (like salt and water) labeling themselves as non-GMO for marketing purposes. This good/bad oversimplification is dangerous, given how essential GMO technology is for addressing humanity’s biggest challenges, such as climate change, global pandemics, and food insecurity.

This conversation needs to change. People need a new model for what GMOs can be. We are building just that, by creating GMO products with genetic engineering that is ethical, transparent, and beneficial to you—the end-user.

Collaborating for ethical engineering

At ZBiotics, we believe in strength through collaboration. That’s why we’re teaming up with other pioneering organizations to build frameworks for the responsible use of genetic engineering.

Frequently Asked Questions

Find answers to common questions about our products and services.

Yes. We are excited to announce that we have launched our second product and now have two products, built with the same technology but for different purposes:

ZBiotics® Pre-Alcohol

For easier mornings after drinking.

Our original product, built to help you land on your feet the day after drinking alcohol by breaking down an unwanted byproduct called acetaldehyde while you drink and while you sleep—setting you up for a great next morning.

ZBiotics Pre-Alcohol (or Pre-Alcohol for short) is a beverage containing a patented, genetically engineered probiotic (B. subtilis ZB183™) that helps you land on your feet the day after drinking alcohol. It’s engineered to break down an unwanted byproduct of alcohol called acetaldehyde – the main culprit behind rough mornings after drinking (citation).

Pre-Alcohol is designed to replicate the natural process of your liver, but do it in your gut. We took a normal probiotic bacteria you already eat every day, and we bioengineered it to produce the same type of enzyme your liver produces (citation). That enzyme breaks down acetaldehyde – an unwanted byproduct of alcohol that accumulates in your gut when you drink.

Your liver does not have access to your gut. But by drinking Pre-Alcohol, the goal is to augment your gut’s natural ability to digest acetaldehyde while you drink and while you sleep – helping you make the most of the next day. Just remember that Pre-Alcohol won’t affect intoxication or make alcohol safer to drink, so always drink responsibly.

ZBiotics Sugar-to-Fiber (or “Sugar-to-Fiber” for short) is a drink mix containing a patented, genetically engineered probiotic (B. subtilis ZB423™) that converts a small amount of the sugar you eat every day into fiber.

Specifically, Sugar-to-Fiber produces an enzyme called levansucrase, which breaks down molecules of a sugar called sucrose (also known as table sugar) and uses the components as building blocks to create a fiber called levan (a prebiotic fiber that is rare in most diets).

Sugar-to-Fiber contains a genetically engineered probiotic, Bacillus subtilis ZB423™, that takes a sugar called sucrose (table sugar) and uses it to create a fiber called levan. It does this by producing an enzyme called levansucrase.

When you mix Sugar-to-Fiber into your drink, the probiotic bacteria are naturally dormant and in a protective state called an endospore. The bacteria in this endospore form can travel safely through your stomach and make it to the intestines, where they will “wake up” and start producing the enzyme levansucrase. This enzyme is capable of breaking down the sucrose you consume into its two individual molecular components: glucose and fructose. It then strings together the free fructose molecules into long chains to make molecules of levan fiber.

Remember: at a molecular level, fibers are just long strings of simple sugars, but their different structures totally change how your body interacts with them. Levan is a rare and beneficial fiber that supports a healthy and diverse microbiome.

The primary benefits of Sugar-to-Fiber relate to microbiome health. Sugar-to-Fiber is unlikely to break down enough sugar to impact things like caloric intake, blood sugar, or weight.

But it will impact your gut health. Sugar-to-Fiber provides exactly what we know makes your microbiome healthier:

1、More soluble fiber,

2、More fiber diversity,

3、Gradual delivery of fiber throughout the day, and

4、Diversion of intestinal sugar

And the benefits of a healthier microbiome for your body are vast and vary from person to person: better immune function, improved gut-lining integrity, improved bowel function, increased short-chain fatty acid synthesis, better nutrient utilization, improved energy, psychological benefits such as greater desire to exercise and cravings for healthier foods, and more.*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.